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Flattening the curve-How to get better results with small deep-mutational-scanning datasets.

Proteins - 1 Jul 2024

Wirnsberger Gregor, Pritišanac Iva, Oberdorfer Gustav, Gruber Karl

Abstract excerpt

Proteins are used in various biotechnological applications, often requiring the optimization of protein properties by introducing specific amino-acid exchanges. Deep mutational scanning (DMS) is an effective high-throughput method for evaluating the effects of these exchanges on protein function. DMS data can then inform the training of a neural network to predict the impact of mutations. Most approaches use some...

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PMID: 38501649
DOI: 10.1002/prot.26686

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