Integration of persistent Laplacian and pre-trained transformer for protein solubility changes upon mutation.

Abstract excerpt

Protein mutations can significantly influence protein solubility, which results in altered protein functions and leads to various diseases. Despite tremendous effort, machine learning prediction of protein solubility changes upon mutation remains a challenging task as indicated by the poor scores of normalized Correct Prediction Ratio (CPR). Part of the challenge stems from the fact that there is no...

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