Aortic regurgitation provokes phenotypic modulation of smooth muscle cells in the normal ascending aorta.

Abstract excerpt

BACKGROUND: Aortic complications are more likely to occur in patients with ascending aortic aneurysms and concomitant aortic regurgitation (AR). AR may have a negative influence on the aortic wall structure even in patients with tricuspid aortic valves and absence of aortic dilatation. It is unknown whether smooth muscle cell (SMC) changes are a feature of AR-associated aortic remodeling. METHODS: Nondilated...

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