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Maternal protein deficiency alters primary cilia length in renal tubular and impairs kidney development in fetal rat

6 Jul 2023

Abstract excerpt

Introduction Intrauterine malnutrition impairs embryo kidney development and leads to kidney disease and hypertension in adulthood, yet the underlying mechanism remains unclear. Methods With a maternal protein restriction (MPR) rat model, we investigated the critical ciliogenesis factors and β-catenin pathway in FGR fetal kidneys and analyzed the impact of aberrant primary cilia on renal tubular epithelium....

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PMID: 37485393
DOI: 10.3389/fnut.2023.1156029

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