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Biological and Biochemical Evaluation of Isatin-Isoniazid Hybrids as Bactericidal Candidates against Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 16 Jul 2021

Johansen Matt D, Shalini, Kumar Sumit, Raynaud Clément, Quan Diana H, Britton Warwick J, Hansbro Philip M, Kumar Vipan, Kremer Laurent

Abstract excerpt

Tuberculosis remains a leading cause of mortality among infectious diseases worldwide, prompting the need to discover new drugs to fight this disease. We report here the design, synthesis, and antimycobacterial activity of isatin-mono/bis-isoniazid hybrids. Most of the compounds exhibited very high activity against Mycobacterium tuberculosis, with MICs in the range of 0.195 to 0.39 μg/ml, and exerted a more...

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PMID: 33972252
DOI: 10.1128/AAC.00011-21
PMCID: PMC8284457

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