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Article

Causal effects of cholelithiasis on hepatopancreatobiliary diseases: a multi-cohort Mendelian randomization study.

BMC gastroenterology - 25 Jun 2026

An Jiawei, Li Xue, Fu Yangsuolang, Xie Huien, Gao Kai, Zeng Fuhao, Wang Yao, Zhu Mingyan, Xiong Yicheng

Abstract excerpt

BACKGROUND: Cholelithiasis is commonly associated with multiple hepatopancreatobiliary diseases, yet whether these relationships reflect causal mechanisms or shared risk factors remains unclear. METHODS: We performed a phenome-oriented two-sample Mendelian randomization (MR) analysis to evaluate the causal impact of genetic liability to cholelithiasis across hepatopancreatobiliary outcomes. Independent...

Read the complete abstract on PubMed

Topics

Mendelian Randomization Analysis
Cholelithiasis
Humans
Genetic Predisposition to Disease
Pancreatitis
Cholangiocarcinoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Bile Duct Neoplasms

Risk Factors

Genome-Wide Association Study

Polymorphism, Single Nucleotide

Liver Diseases

Body Mass Index

Source

Open in PubMed Open full text

Identifiers

PMID: 42350965
DOI: 10.1186/s12876-026-05033-8
PMCID: PMC13556059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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