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Article

Sustained T Cell Immunity, Protection and Boosting Using Extended Dosing Intervals of BNT162b2 mRNA Vaccine

2021-07-21

Abstract excerpt

Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the UK to accelerate population coverage with a single dose. In a study of 503 healthcare workers, we show that after priming following the first vaccine there is a marked decline in SARS-CoV-2 neutralizing antibody (NAb) levels, but, in contrast, a sustained T cell response to spike protein. This divergent immune profi...

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Literature Corpus work
ca0ee977-49f8-572a-a25f-d62535b959e0
DOI
10.2139/ssrn.3891065
Open publication

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Sustained T Cell Immunity, Protection and Boosting Using Extended Dosing Intervals of BNT162b2 mRNA VaccineDOI 10.2139/ssrn.3891065
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