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The humoral and cellular response to mRNA SARS-CoV-2 vaccine is influenced by HLA polymorphisms.

HLA - 1 Sept 2023

Bertinetto Francesca Eleonora, Magistroni Paola, Mazzola Gina Adriana, Costa Cristina, Elena Garino, Alizzi Silvia, Scozzari Gitana, Migliore Enrica, Galassi Claudia, Ciccone Giovannino, Ricciardelli Guido, Scarmozzino Antonio, Angelone Lorenzo, Cassoni Paola, Cavallo Rossana, Vaisitti Tiziana, Deaglio Silvia, Amoroso Antonio

Abstract excerpt

Host genetic variability contributes to susceptibility to SARS-CoV-2 infection and COVID-19 evolution and the role of HLA system has not clearly emerged, suggesting the involvement of other factors. Studying response to vaccination with Spyke protein mRNA represents an ideal model to highlight whether the humoral or cellular responses are influenced by HLA. Four hundred and sixteen workers, vaccinated with...

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PMID: 37010080
DOI: 10.1111/tan.15049

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