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Article

The effect of sex and estrus cycle stage on optogenetic spreading depression induced migraine-like pain phenotypes.

The journal of headache and pain - 19 Jul 2023

Harriott Andrea M, Waruinge Angel, Appiah-Danquah Viola, Berhanu Leah, Morais Andreia, Ayata Cenk

Abstract excerpt

BACKGROUND: Migraine is more prevalent in females, raising the possibility that sex and gonadal hormones modulate migraine. We recently demonstrated that minimally invasive optogenetic spreading depolarization (opto-SD) elicits robust periorbital allodynia. The objective of this study was to test the hypothesis that opto-SD induced migraine-like pain behavior is worse in females and varies during the estrus...

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Source

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Identifiers

PMID: 37464297
DOI: 10.1186/s10194-023-01621-1
PMCID: PMC10355061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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