Article
Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy.
Circulation - 5 Sept 2023
Joy George, Kelly Christopher I, Webber Matthew, Pierce Iain, Teh Irvin, McGrath Louise, Velazquez Paula, Hughes Rebecca K, Kotwal Huafrin, Das Arka, Chan Fiona, Bakalakos Athanasios, Lorenzini Massimiliano, Savvatis Konstantinos, Mohiddin Saidi A, Macfarlane Peter W, Orini Michele, Manisty Charlotte, Kellman Peter, Davies Rhodri H, Lambiase Pier D, Nguyen Christopher, Schneider Jurgen E, Tome Maite, Captur Gabriella, Dall'Armellina Erica, Moon James C, Lopes Luis R
Abstract excerpt
BACKGROUND: In hypertrophic cardiomyopathy (HCM), myocyte disarray and microvascular disease (MVD) have been implicated in adverse events, and recent evidence suggests that these may occur early. As novel therapy provides promise for disease modification, detection of phenotype development is an emerging priority. To evaluate their utility as early and disease-specific biomarkers, we measured myocardial...
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