Article
RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere's disease.
The European journal of neuroscience - 1 Aug 2023
Babu Vidya, Bahari Rose, Laban Nora, Kulaga Jacob, Abdul Zahid, Zakkar Basil, Al-Najjar Ahmad, Lesus Joseph, Al-Rifai Abd-Al-Rahman, Sattar Heba, Irukulla Suhitha, Gunniya Pranav, Requena Teresa, Lysakowski Anna
Abstract excerpt
Meniere's disease (MD) is a disorder of the inner ear characterized by chronic episodes of vertigo, tinnitus, increased aural pressure, and sensorineural hearing loss. Causes of MD are unknown, but endolymphatic hydrops is a hallmark. In addition, 5%-15% of MD cases have been identified as familial. Whole-genome sequencing studies of individuals with familial MD identified DTNA and FAM136A as candidate genes for...
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