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Article

OBOX regulates mouse zygotic genome activation and early development.

Nature - 1 Aug 2023

Ji Shuyan, Chen Fengling, Stein Paula, Wang Jiacheng, Zhou Ziming, Wang Lijuan, Zhao Qing, Lin Zili, Liu Bofeng, Xu Kai, Lai Fangnong, Xiong Zhuqing, Hu Xiaoyu, Kong Tianxiang, Kong Feng, Huang Bo, Wang Qiujun, Xu Qianhua, Fan Qiang, Liu Ling, Williams Carmen J, Schultz Richard M, Xie Wei

Abstract excerpt

Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-zygotic transition1,2. However, the identity of transcription factors that underlie mammalian ZGA in vivo remains elusive. Here we show that OBOX, a PRD-like homeobox domain transcription factor family (OBOX1-OBOX8)3-5, are key regulators of mouse ZGA. Mice deficient for maternally transcribed Obox1/2/5/7 and zygotically...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37459895
DOI: 10.1038/s41586-023-06428-3
PMCID: PMC10528489

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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