Article
Optimisation of warfarin-dosing algorithms for Han Chinese patients with CYP2C9*13 variants.
European journal of clinical pharmacology - 1 Oct 2023
Wang Dongxu, Wu Hualan, Zhang Qing, Zhou Xiaoyue, An Yang, Zhao Anxu, Chong Jia, Wang Shuanghu, Wang Fang, Yang Jiefu, Dai Dapeng, Chen Hao
Abstract excerpt
BACKGROUND: Existing pharmacogenetic algorithms cannot fully explain warfarin dose variability in all patients. CYP2C9*13 is an important allelic variant in the Han Chinese population. However, adjustment of warfarin dosing in CYP2C9*13 variant carriers remains unclear. To the best of our knowledge, this study is the first to assess the effects of adjusting warfarin dosages in Han Chinese patients harbouring...
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