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Article

Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus.

Microbiology spectrum - 17 Aug 2023

Negatu Dereje A, Aragaw Wassihun Wedajo, Dartois Véronique, Dick Thomas

Abstract excerpt

Single-step selection of Mycobacterium abscessus mutants resistant to linezolid yielded high-level resistance at a low frequency that was associated with mutations in 23S rRNA or the ribosomal protein L3. Surprisingly, linezolid-resistant rRNA mutations conferred cross-resistance to several unrelated antibiotics. Low-level linezolid-resistant mutants were isolated at a higher frequency and were due to...

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Source

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Identifiers

PMID: 37458588
DOI: 10.1128/spectrum.02199-23
PMCID: PMC10434030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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