Phase II Randomized Trial of Carboplatin, Pemetrexed, and Bevacizumab With and Without Atezolizumab in Stage IV Nonsquamous Non-Small-Cell Lung Cancer Patients Who Harbor a Sensitizing EGFR Mutation or Have Never Smoked.

doi:10.1016/j.cllc.2023.05.003

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Phase II Randomized Trial of Carboplatin, Pemetrexed, and Bevacizumab With and Without Atezolizumab in Stage IV Nonsquamous Non-Small-Cell Lung Cancer Patients Who Harbor a Sensitizing EGFR Mutation or Have Never Smoked.

Clinical lung cancer - 1 Nov 2023

Bodor J Nicholas, Patel Jyoti D, Wakelee Heather A, Levy Benjamin P, Borghaei Hossein, Pellini Bruna, Costello Michael R, Dowell Jonathan E, Finley Gene, Huang Chao H, Neal Joel W, Nieva Jorge J, Puri Sonam, Socinski Mark A, Thomas Christian, Ross Eric A, Litwin Samuel, Clapper Margie L, Treat Joseph

Abstract excerpt

INTRODUCTION: Patients with non-small-cell lung cancer (NSCLC) who have never smoked or have tumors with mutations in EGFR generally derive minimal benefit from single-agent PD-1/PD-L1 checkpoint inhibitors. Prior data indicate that adding PD-L1 inhibition to anti-VEGF and cytotoxic chemotherapy may be a promising approach to overcoming immunotherapy resistance in these patients, however prospective validation is...

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PMID: 37451930
DOI: 10.1016/j.cllc.2023.05.003
PMCID: PMC11476834

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