Atezolizumab with or without bevacizumab and platinum-pemetrexed in patients with stage IIIB/IV non-squamous non-small cell lung cancer with EGFR mutation, ALK rearrangement or ROS1 fusion progressing after targeted therapies: A multicentre phase II open-label non-randomised study GFPC 06-2018.

doi:10.1016/j.ejca.2023.01.014

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Atezolizumab with or without bevacizumab and platinum-pemetrexed in patients with stage IIIB/IV non-squamous non-small cell lung cancer with EGFR mutation, ALK rearrangement or ROS1 fusion progressing after targeted therapies: A multicentre phase II open-label non-randomised study GFPC 06-2018.

European journal of cancer (Oxford, England : 1990) - 1 Apr 2023

Bylicki Olivier, Tomasini Pascale, Radj Gervais, Guisier Florian, Monnet Isabelle, Ricordel Charles, Bigay-Game Laurence, Geier Margaux, Chouaid Christos, Daniel Catherine, Swalduz Aurelie, Toffart Anne-Claire, Doubre Helene, Peloni Jean-Michel, Moreau Diane, Subtil Fabien, Grellard Jean-Michel, Castera Marie, Clarisse Benedicte, Martins-Lavinas Pedro-Henrique, Decroisette Chantal, Greillier Laurent

Abstract excerpt

BACKGROUND: Previous reports showed limited efficacy of immune checkpoint inhibitors as single-agent treatment for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation or ALK/ROS1 fusion. We aimed at evaluating the efficacy and safety of immune checkpoint inhibitor combined with chemotherapy and bevacizumab (when eligible) in this patient subgroup. METHODS: We conducted a...

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PMID: 36801605
DOI: 10.1016/j.ejca.2023.01.014

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