A Randomized Phase II Study Comparing Nivolumab With Carboplatin-Pemetrexed for Patients With EGFR Mutation-Positive Nonsquamous Non-Small-Cell Lung Cancer Who Acquire Resistance to Tyrosine Kinase Inhibitors Not Due to a Secondary T790M Mutation: Rationale and Protocol Design for the WJOG8515L Study.

doi:10.1016/j.cllc.2017.05.012

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A Randomized Phase II Study Comparing Nivolumab With Carboplatin-Pemetrexed for Patients With EGFR Mutation-Positive Nonsquamous Non-Small-Cell Lung Cancer Who Acquire Resistance to Tyrosine Kinase Inhibitors Not Due to a Secondary T790M Mutation: Rationale and Protocol Design for the WJOG8515L Study.

Clinical lung cancer - 1 Nov 2017

Hayashi Hidetoshi, Chiba Yasutaka, Sakai Kazuko, Fujita Tomonobu, Yoshioka Hiroshige, Sakai Daisuke, Kitagawa Chiyoe, Naito Tateaki, Takeda Koji, Okamoto Isamu, Mitsudomi Tetsuya, Kawakami Yutaka, Nishio Kazuto, Nakamura Shinichiro, Yamamoto Nobuyuki, Nakagawa Kazuhiko

Abstract excerpt

Antibodies to programmed cell death-1 (PD-1), such as nivolumab, have shown promising clinical activity in patients with advanced non-small-cell lung cancer (NSCLC), but their efficacy appears to be less pronounced in patients with such tumors harboring epidermal growth factor receptor gene (EGFR) mutations. Recent findings suggest that patients with EGFR mutation-positive NSCLC who develop resistance to tyrosine...

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PMID: 28623122
DOI: 10.1016/j.cllc.2017.05.012

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