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Article

Beta Elemene induces cytotoxic effects in FLT3 ITD-mutated acute myeloid leukemia by modulating apoptosis.

European review for medical and pharmacological sciences - 1 Apr 2023

Alafnan A, Dogan R, Bender O, Celik I, Mollica A, Malik J A, Rengasamy K R R, Break M K B, Khojali W M A, Alharby T N, Atalay A, Anwar S

Abstract excerpt

OBJECTIVE: β-Elemene, a sesquiterpene with a broad anti-cancer spectrum, is particularly effective against drug-resistant and complex tumors. It can also be efficient against FLT3-expressed acute myeloid leukemia. This research aims to determine whether β-Elemene has cytotoxic effects on FLT3 ITD-mutated AML cells. MATERIALS AND METHODS: Cytotoxicity, cell morphology, mRNA analysis with apoptotic markers, and...

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Identifiers

PMID: 37140277
DOI: 10.26355/eurrev_202304_32098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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