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HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)

8 Jan 2021

Abstract excerpt

The Intact Proviral DNA Assay (IPDA) was developed to address the critical need for a scalable method for intact HIV-1 reservoir quantification. This droplet digital PCR-based assay simultaneously targets two HIV-1 regions to distinguish genomically intact proviruses against a large background of defective ones, and its application has yielded insights into HIV-1 persistence. Reports of assay failures however,...

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PMID: 33420062
DOI: 10.1038/s41467-020-20442-3

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