Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease.

Advances in experimental medicine and biology - 1 Jan 2023

Grunin Michelle, Palmer Ellen, de Jong Sarah, Jin Bowen, Rinker David, Moth Christopher, Capra John A, Haines Jonathan L, Bush William S, den Hollander Anneke I

Abstract excerpt

Protein function can be impacted by changes in protein structure stability, but determining which change has impact is complex. Stability can be affected by a large change in the tertiary (3D) structure of the protein or due to free-energy changes caused by single amino acid substitutions. Changes in the DNA sequence can have minor or major impact on protein stability, which can lead to disease. Inherited retinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Macular Degeneration
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Stability

Share to Proteins

Share to Retina

Share to Retinal Degeneration

Source

Identifiers

PMID: 37440029
DOI: 10.1007/978-3-031-27681-1_24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease.PMID 37440029Read ↗

Computational approaches for predicting mutant protein stability.Semantic proximity Read ↗

Correlating protein function and stability through the analysis of single amino acid substitutions.Semantic proximity Read ↗

Review of predicting protein stability changes upon variations.Semantic proximity Read ↗

Structural and Pathogenic Impacts of ABCA4 Variants in Retinal Degenerations-An In-Silico Study.Semantic proximity Read ↗

Identification of pathogenic missense mutations using protein stability predictors.Semantic proximity Read ↗

Identification of pathogenic missense mutations using protein stability predictorsSemantic proximity Read ↗

Analyzing effects of naturally occurring missense mutations.Semantic proximity Read ↗

Towards predictive biophysical and mechanistic models for disease-causing protein variantsSemantic proximity Read ↗

Investigating the linkage between disease-causing amino acid variants and their effect on protein stability and binding.Semantic proximity Read ↗

StabilitySort: assessment of protein stability changes on a genome-wide scale to prioritize potentially pathogenic genetic variation.Semantic proximity Read ↗

Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins.Semantic proximity Read ↗

Performance of protein stability predictors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.