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Article

Evaluation of Somatic Mutations in Urine Samples as a Noninvasive Method for the Detection and Molecular Classification of Endometrial Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2023

Costas Laura, Onieva Irene, Pelegrina Beatriz, Marin Fátima, Carmona Álvaro, López-Querol Marta, Frias-Gomez Jon, Peremiquel-Trillas Paula, Martínez José Manuel, Dorca Eduard, Brunet Joan, Pineda Marta, Ponce Jordi, Matias-Guiu Xavier, de Sanjosé Silvia, Bosch Francesc Xavier, Alemany Laia, Paytubi Sonia

Abstract excerpt

PURPOSE: Current diagnostic methods for endometrial cancer lack specificity, leading to many women undergoing invasive procedures. The aim of this study was to evaluate somatic mutations in urine to accurately discriminate patients with endometrial cancer from controls. EXPERIMENTAL DESIGN: Overall, 72 samples were analyzed using next-generation sequencing (NGS) with molecular identifiers targeting 47 genes. We...

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PMID: 37439797
DOI: 10.1158/1078-0432.CCR-23-0367

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