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Next-generation sequencing reveals mitogenome diversity in plasma extracellular vesicles from colorectal cancer patients

12 Jul 2023

Abstract excerpt

BACKGROUND: Recent reports have demonstrated that the entire mitochondrial genome can be secreted in extracellular vesicles (EVs), but the biological attributes of this cell-free mitochondrial DNA (mtDNA) remain insufficiently understood. We used next-generation sequencing to compare plasma EV-derived mtDNA to that of whole blood (WB), peripheral blood mononuclear cells (PBMCs), and formalin-fixed...

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PMID: 37438741
DOI: 10.1186/s12885-023-11092-x

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