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Article

Genetic association of nuclear factor of activated T cells' 3'UTR and structural polymorphisms with susceptibility to generalized vitiligo in Gujarat population.

Gene - 5 Sept 2023

Giri Prashant, Bhimani Radhika, Patil Siddhika, Dwivedi Mitesh

Abstract excerpt

Generalized vitiligo (GV) is an autoimmune skin depigmenting disease characterized by loss of functional melanocytes. Nuclear factor of activated T cells (NFATs) play a key role in regulatory T cells' (Tregs) activation and function. Our previous studies have highlighted the role of reduced NFATs expression and activity in impaired Tregs suppressive capacity, leading to GV pathogenesis. 3'UTR region and...

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PMID: 37429370
DOI: 10.1016/j.gene.2023.147629

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