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Article

Feature weighted models to address lineage dependency in drug-resistance prediction from Mycobacterium tuberculosis genome sequences.

Bioinformatics (Oxford, England) - 1 Jul 2023

Billows Nina, Phelan Jody E, Xia Dong, Peng Yonghong, Clark Taane G, Chang Yu-Mei

Abstract excerpt

MOTIVATION: Tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis complex (MTBC), which has a strain- or lineage-based clonal population structure. The evolution of drug-resistance in the MTBC poses a threat to successful treatment and eradication of TB. Machine learning approaches are being increasingly adopted to predict drug-resistance and characterize underlying mutations from whole genome...

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Identifiers

PMID: 37428143
DOI: 10.1093/bioinformatics/btad428
PMCID: PMC10351970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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