Development and Validation of the Nonalcoholic Fatty Liver Disease Familial Risk Score to Detect Advanced Fibrosis: A Prospective, Multicenter Study.

doi:10.1016/j.cgh.2023.06.020

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Development and Validation of the Nonalcoholic Fatty Liver Disease Familial Risk Score to Detect Advanced Fibrosis: A Prospective, Multicenter Study.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jan 2024

Huang Daniel Q, Ahlholm Noora, Luukkonen Panu K, Porthan Kimmo, Amangurbanova Maral, Madamba Egbert, Bettencourt Richele, Siddiqi Harris, Cervantes Vanessa, Hernandez Christie, Lopez Scarlett J, Richards Lisa, Nemes Katriina, Isoniemi Helena, Yki-Järvinen Hannele, Loomba Rohit

Abstract excerpt

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD)-related fibrosis is heritable, but it is unclear how family history may be used to identify first-degree relatives with advanced fibrosis. We aimed to develop and validate a simple risk score to identify first-degree relatives of probands who have undergone assessment of liver fibrosis who are at higher risk of NAFLD with advanced fibrosis. METHODS: This...

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PMID: 37406954
DOI: 10.1016/j.cgh.2023.06.020
PMCID: PMC11160482

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