Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Telomerase reverse transcriptase immunohistochemical expression is sensitive but not specific for TERT gene amplification in acral melanoma.

Journal of cutaneous pathology - 1 Sept 2023

Cho Woo Cheal, Li Wen, Gu Jun, Wang Wei-Lien, Ning Jing, Sfamenos Steven, Gill Pavandeep, Nagarajan Priyadharsini, Curry Jonathan L, Lazar Alexander J, Prieto Victor G, Torres-Cabala Carlos A, Aung Phyu P

Abstract excerpt

BACKGROUND: TERT gene amplification (TGA) is a mechanism of telomerase reverse transcriptase (TERT) upregulation frequently utilized by acral melanomas (AMs). Currently, the utility of TERT immunohistochemistry (IHC) to predict TGA status in AMs is poorly documented. METHODS: AMs (26 primary and 3 metastatic) and non-acral cutaneous melanomas (6 primary) were subjected to immunohistochemical analysis using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Amplification
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma

Share to Melanoma, Cutaneous Malignant

Share to Mutation

Share to Skin Neoplasms

Share to Telomerase

Source

Identifiers

PMID: 37400233
DOI: 10.1111/cup.14494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Telomerase reverse transcriptase immunohistochemical expression is sensitive but not specific for TERT gene amplification in acral melanoma.PMID 37400233Read ↗

Telomerase Reverse Transcriptase Protein Expression Is More Frequent in Acral Lentiginous Melanoma Than in Other Types of Cutaneous MelanomaSemantic proximity Read ↗

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma.Semantic proximity Read ↗

Genetic and Epigenetic Alterations of TERT Are Associated with Inferior Outcome in Adolescent and Young Adult Patients with MelanomaSemantic proximity Read ↗

Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas.Semantic proximity Read ↗

The genetic evolution of acral melanomaSemantic proximity Read ↗

TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinoma.Semantic proximity Read ↗

TERT promoter mutation is uncommon in acral lentiginous melanoma.Semantic proximity Read ↗

TERT Promoter Mutations and Telomerase in MelanomaSemantic proximity Read ↗

Acral melanoma: correlating the clinical presentation to the mutational status.Semantic proximity Read ↗

TERT and TERT promoter in melanocytic neoplasms: Current concepts in pathogenesis, diagnosis, and prognosis.Semantic proximity Read ↗

MAPK Pathway and TERT Promoter Gene Mutation Pattern and Its Prognostic Value in Melanoma Patients: A Retrospective Study of 2,793 Cases.Semantic proximity Read ↗

Analysis of KIT expression and gene mutation in human acral melanoma: with a comparison between primary tumors and corresponding metastases/recurrences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.