Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis.

doi:10.1182/blood.2023019758

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Article

Resolving therapy resistance mechanisms in multiple myeloma by multiomics subclone analysis.

Blood - 9 Nov 2023

Poos Alexandra M, Prokoph Nina, Przybilla Moritz J, Mallm Jan-Philipp, Steiger Simon, Seufert Isabelle, John Lukas, Tirier Stephan M, Bauer Katharina, Baumann Anja, Rohleder Jennifer, Munawar Umair, Rasche Leo, Kortüm K Martin, Giesen Nicola, Reichert Philipp, Huhn Stefanie, Müller-Tidow Carsten, Goldschmidt Hartmut, Stegle Oliver, Raab Marc S, Rippe Karsten, Weinhold Niels

Abstract excerpt

Intratumor heterogeneity as a clinical challenge becomes most evident after several treatment lines, when multidrug-resistant subclones accumulate. To address this challenge, the characterization of resistance mechanisms at the subclonal level is key to identify common vulnerabilities. In this study, we integrate whole-genome sequencing, single-cell (sc) transcriptomics (scRNA sequencing), and chromatin...

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Identifiers

PMID: 37390336
DOI: 10.1182/blood.2023019758
PMCID: PMC10733835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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