Article
Single-cell analysis of targeted transcriptome predicts drug sensitivity of single cells within human myeloma tumors.
Leukemia - 1 May 2016
Mitra A K, Mukherjee U K, Harding T, Jang J S, Stessman H, Li Y, Abyzov A, Jen J, Kumar S, Rajkumar V, Van Ness B
Abstract excerpt
Multiple myeloma (MM) is characterized by significant genetic diversity at subclonal levels that have a defining role in the heterogeneity of tumor progression, clinical aggressiveness and drug sensitivity. Although genome profiling studies have demonstrated heterogeneity in subclonal architecture that may ultimately lead to relapse, a gene expression-based prediction program that can identify, distinguish and...
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