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Article

KR4SL: knowledge graph reasoning for explainable prediction of synthetic lethality.

Bioinformatics (Oxford, England) - 30 Jun 2023

Zhang Ke, Wu Min, Liu Yong, Feng Yimiao, Zheng Jie

Abstract excerpt

MOTIVATION: Synthetic lethality (SL) is a promising strategy for anticancer therapy, as inhibiting SL partners of genes with cancer-specific mutations can selectively kill the cancer cells without harming the normal cells. Wet-lab techniques for SL screening have issues like high cost and off-target effects. Computational methods can help address these issues. Previous machine learning methods leverage known SL...

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Identifiers

PMID: 37387166
DOI: 10.1093/bioinformatics/btad261
PMCID: PMC10311291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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