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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections

29 Jun 2023

Abstract excerpt

Millions who live in Latin America and sub-Saharan Africa are at risk of trypanosomatid infections, which cause Chagas disease and human African trypanosomiasis (HAT). Improved HAT treatments are available, but Chagas disease therapies rely on two nitroheterocycles, which suffer from lengthy drug regimens and safety concerns that cause frequent treatment discontinuation. We performed phenotypic screening against...

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PMID: 37384702
DOI: 10.1126/science.adh0614

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