Article
Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity.
Journal of medicinal chemistry - 22 May 2014
Álvarez Guzmán, Varela Javier, Márquez Pablo, Gabay Martín, Arias Rivas Carmen Elena, Cuchilla Karina, Echeverría Gustavo A, Piro Oscar E, Chorilli Marlus, Leal Sandra M, Escobar Patricia, Serna Elva, Torres Susana, Yaluff Gloria, Vera de Bilbao Ninfa I, González Mercedes, Cerecetto Hugo
Abstract excerpt
Chagas disease, caused by Trypanosoma cruzi parasite, was described thousands of years ago. Currently, it affects millions of people, mostly in Latin America, and there are not suitable drugs for treating it. As an attempt to find appropriate drugs to deal with this problem, we report here on the design, synthesis, and characterization of 82 new compounds. Trypanosomicidal behavior in vitro showed more than 20...
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