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Article

Context-dependent environmental associations with endometrial cancer histotype and genotype.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 7 Aug 2023

Nakad Borrego Sanaa, Kurnit Katherine, Turner Laura Jane, Broaddus Russell R

Abstract excerpt

OBJECTIVE: MLH1 loss due to MLH1 methylation, detected during Lynch syndrome screening, is one of the most common molecular changes in endometrial cancer. It is well established that environmental influences such as nutritional state can impact gene methylation, both in the germline and in a tumor. In colorectal cancer and other cancer types, aging is associated with changes in gene methylation. The objective of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37380216
DOI: 10.1136/ijgc-2023-004330
PMCID: PMC10823374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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