Article
Treatment of Colistin Dependence-Developing Acinetobacter baumannii with Antibiotic Combinations at Subinhibitory Concentrations.
Microbial drug resistance (Larchmont, N.Y.) - 1 Oct 2023
Jo Jeongwoo, Lee Ji Young, Cho Hongbaek, Ko Kwan Soo
Abstract excerpt
Recent studies have revealed that colistin dependence frequently develops in colistin-susceptible Acinetobacter baumannii isolates. Despite resistance in parental strains, colistin-dependent mutants showed increased susceptibility to several antibiotics, which suggests the possibility of developing strategies to eliminate multidrug-resistant (MDR) A. baumannii. We investigated in vitro and in vivo efficacy of...
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