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Article

Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates

28 Jun 2023

Abstract excerpt

Notch signaling promotes T cell pathogenicity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the Delta-like Notch ligand DLL4. To assess whether Notch's effects are evolutionarily conserved and to identify the mechanisms of Notch signaling inhibition, we studied antibody-mediated DLL4 blockade in a nonhuman primate (NHP) model...

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PMID: 37379368
DOI: 10.1126/scitranslmed.add1175

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