Article
A Functional Genetic Screen Identifies the Phosphoinositide 3-kinase Pathway as a Determinant of Resistance to Fibroblast Growth Factor Receptor Inhibitors in FGFR Mutant Urothelial Cell Carcinoma.
European urology - 1 Jun 2017
Wang Liqin, Šuštić Tonći, Leite de Oliveira Rodrigo, Lieftink Cor, Halonen Pasi, van de Ven Marieke, Beijersbergen Roderick L, van den Heuvel Michel M, Bernards René, van der Heijden Michiel S
Abstract excerpt
Activating mutations and translocations of the FGFR3 gene are commonly seen in urothelial cell carcinoma (UCC) of the bladder and urinary tract. Several fibroblast growth factor receptor (FGFR) inhibitors are currently in clinical development and response rates appear promising for advanced UCC. A common problem with targeted therapeutics is intrinsic or acquired resistance of the cancer cells. To find potential...
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