Article
CDK12 alterations and ARID1A mutations are predictors of poor prognosis and therapeutic targets in high-grade salivary gland carcinoma: analysis of the National Genomic Profiling Database.
Japanese journal of clinical oncology - 30 Aug 2023
Kobayashi Kenya, Saito Yuki, Kage Hidenori, Fukuoka Osamu, Yamamura Koji, Mukai Toshiyuki, Oda Katsutoshi, Yamasoba Tatsuya
Abstract excerpt
BACKGROUND: Due to the diversity of histopathologic types in salivary gland carcinoma, genomic analysis of large cohorts with next-generation sequencing by histologic type has not been adequately performed. METHODS: We analysed data from 93 patients with salivary duct carcinoma and 243 patients with adenoid cystic carcinoma who underwent comprehensive genomic profiling testing in the Center for Cancer Genomics...
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