Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.

doi:10.3390/genes11070775

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Evolutionary History of the Risk of SNPs for Diffuse-Type Gastric Cancer in the Japanese Population.

Genes - 10 Jul 2020

Iwasaki Risa L, Ishiya Koji, Kanzawa-Kiriyama Hideaki, Kawai Yosuke, Gojobori Jun, Satta Yoko

Abstract excerpt

A genome wide association study reported that the T allele of rs2294008 in a cancer-related gene, PSCA, is a risk allele for diffuse-type gastric cancer. This allele has the highest frequency (0.63) in Japanese in Tokyo (JPT) among 26 populations in the 1000 Genomes Project database. FST ≈ 0.26 at this single nucleotide polymorphism is one of the highest between JPT and the genetically close Han Chinese in...

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PMID: 32664326
DOI: 10.3390/genes11070775
PMCID: PMC7396988

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