Article
Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2023
King Sontoria D, Veliginti Swathi, Brouwers Martijn C G J, Ren Zhewen, Zheng Wei, Setiawan Veronica W, Wilkens Lynne R, Shu Xiao-Ou, Arslan Alan A, Beane Freeman Laura E, Bracci Paige M, Canzian Federico, Du Mengmeng, Gallinger Steven J, Giles Graham G, Goodman Phyllis J, Haiman Christopher A, Kogevinas Manolis, Kooperberg Charles, LeMarchand Loic, Neale Rachel E, Visvanathan Kala, White Emily, Albanes Demetrius, Andreotti Gabriella, Babic Ana, Berndt Sonja I, Brais Lauren K, Brennan Paul, Buring Julie E, Rabe Kari G, Bamlet William R, Chanock Stephen J, Fuchs Charles S, Gaziano J Michael, Giovannucci Edward L, Hackert Thilo, Hassan Manal M, Katzke Verena, Kurtz Robert C, Lee I-Min, Malats Núria, Murphy Neil, Oberg Ann L, Orlow Irene, Porta Miquel, Real Francisco X, Rothman Nathaniel, Sesso Howard D, Silverman Debra T, Thompson Ian M, Wactawski-Wende Jean, Wang Xiaoliang, Wentzensen Nicolas, Yu Herbert, Zeleniuch-Jacquotte Anne, Yu Kai, Wolpin Brian M, Duell Eric J, Li Donghui, Hung Rayjean J, Perdomo Sandra, McCullough Marjorie L, Freedman Neal D, Patel Alpa V, Peters Ulrike, Riboli Elio, Sund Malin, Tjønneland Anne, Zhong Jun, Van Den Eeden Stephen K, Kraft Peter, Risch Harvey A, Amundadottir Laufey T, Klein Alison P, Stolzenberg-Solomon Rachael Z, Antwi Samuel O
Abstract excerpt
BACKGROUND: There are conflicting data on whether nonalcoholic fatty liver disease (NAFLD) is associated with susceptibility to pancreatic cancer. Using Mendelian randomization (MR), we investigated the relationship between genetic predisposition to NAFLD and risk for pancreatic cancer. METHODS: Data from genome-wide association studies (GWAS) within the Pancreatic Cancer Cohort Consortium (PanScan; cases n =...
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