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Article

Biomarkers in cerebrospinal fluid for amyotrophic lateral sclerosis phenotypes.

Annals of clinical and translational neurology - 1 Aug 2023

Zhou Jinxia, Zeng Qianqian, Liao Qiao, Niu Qi, Gu Wenping, Su Dandan, Li Sizhuo, Xiao Bo, Bi Fangfang

Abstract excerpt

OBJECTIVE: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower motor neurons. The motor phenotypes of ALS are highly clinically heterogeneous, and the underlying mechanisms are poorly understood. METHODS: A comparative proteomic analysis was performed in the cerebrospinal fluid (CSF) of bulbar-onset (BO) and spinal-onset (SO) ALS patients and controls...

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Identifiers

PMID: 37350306
DOI: 10.1002/acn3.51836
PMCID: PMC10424661

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