Article
Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes.
JAMA neurology - 1 Jun 2017
Zhao Weihua, Beers David R, Hooten Kristopher G, Sieglaff Douglas H, Zhang Aijun, Kalyana-Sundaram Shanker, Traini Christopher M, Halsey Wendy S, Hughes Ashley M, Sathe Ganesh M, Livi George P, Fan Guo-Huang, Appel Stanley H
Abstract excerpt
Importance: Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by selective loss of upper and lower motor neurons. Patients with ALS have persistent peripheral and central inflammatory responses including abnormally functioning T cells and activated microglia. However, much less is known about the inflammatory gene profile of circulating innate immune monocytes in...
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