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Article

Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in Acinetobacter baumannii.

mSystems - 31 Aug 2023

Liu Xiaochen, Chang Yunjie, Xu Qingye, Zhang Wang, Huang Zhen, Zhang Linyue, Weng Shanshan, Leptihn Sebastian, Jiang Yan, Yu Yunsong, Hua Xiaoting

Abstract excerpt

Acinetobacter baumannii has become one of the most challenging pathogens in many countries with limited treatment options available. Cefiderocol, a novel siderophore-conjugated cephalosporin, shows potent in vitro activity against A. baumannii, including isolates resistant to carbapenems. To date, few reports on the mechanisms of cefiderocol resistance are available. In order to investigate potential mechanisms...

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Identifiers

PMID: 37345941
DOI: 10.1128/msystems.01291-22
PMCID: PMC10469669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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