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A novel extrachromosomal circular DNA related genes signature for overall survival prediction in patients with ovarian cancer

19 Jun 2023

Abstract excerpt

OBJECTIVE: Ovarian cancer (OV) has a high mortality rate all over the world, and extrachromosomal circular DNA (eccDNA) plays a key role in carcinogenesis. We wish to study more about the molecular structure of eccDNA in the UACC-1598-4 cell line and how its genes are associated with ovarian cancer prognosis. METHODS: We sequenced and annotated the eccDNA by Circle_seq of the OV cell line UACC-1598-4. To acquire...

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PMID: 37337170
DOI: 10.1186/s12920-023-01576-x

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