Article
Generation of an induced pluripotent stem cell line (EURACi014-A) from a Parkinson's disease patient with an A53T mutation in the SNCA gene by an integration-free reprogramming method.
Stem cell research - 1 Apr 2022
Gilmozzi Valentina, Gentile Giovanna, Riekschnitz Diana A, Volpato Claudia B, Di Segni Marina, Silipigni Rosamaria, Pramstaller Peter P, Hicks Andrew A, Pichler Irene, Zanon Alessandra
Abstract excerpt
The SNCA gene encodes the presynaptic α-synuclein (aSyn) protein, and its mutations are associated with autosomal dominant Parkinson's disease (PD). We describe the generation of an induced pluripotent stem cell (iPSC) line of a patient carrying a pathogenic Ala53Thr missense mutation in the SNCA gene. Human dermal fibroblasts were reprogrammed using a non-integrating episomal method. The generated iPSC line...
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