Article
Loss of miR-936 leads to acquisition of androgen-independent metastatic phenotype in prostate cancer.
Scientific reports - 12 Oct 2022
Edachery Sarathkumar, Patil Prakash, Mohan Rajashekar, Aradhya Bhuvanesh, Shetty Jayaprakash, Kabekkodu Shama Prasada, Santra Manas Kumar, Gonchigar Sathisha Jayanna, Shetty Praveenkumar
Abstract excerpt
Prostate cancer (PCa) progresses from a hormone-sensitive, androgen-dependent to a hormone-refractory, androgen-independent metastatic phenotype. Among the many genes implicated, ANXA2, a calcium-dependent phospholipid binding protein, has been found to have a critical role in the progression of PCa into more invasive metastatic phenotype. However, the molecular mechanisms underlying the absence of ANXA2 in early...
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