Article
Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution.
Human molecular genetics - 15 Sept 2017
Mägi Reedik, Horikoshi Momoko, Sofer Tamar, Mahajan Anubha, Kitajima Hidetoshi, Franceschini Nora, McCarthy Mark I, Morris Andrew P
Abstract excerpt
Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse populations can increase power to detect complex trait loci when the underlying causal variants are shared between ancestry groups. However, heterogeneity in allelic effects between GWAS at these loci can occur that is correlated with ancestry. Here, a novel approach is presented to detect SNP association and quantify the extent...
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