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Article

Inhibition of protein arginine deiminase II suppresses retinoblastoma in orthotopic transplantation in mice.

Oncology reports - 1 Jul 2023

Kim Sojin, Song Yong Keun, Cho Chang Sik, Kim Hyo Jung, Fang Sungsoon, Jo Dong Hyun, Kim Hyunkyung

Abstract excerpt

Chemotherapies are used for treating retinoblastoma; however, numerous patients suffer from recurrence or symptoms due to chemotherapy, which emphasizes the need for alternative therapeutic strategies. The present study demonstrated that protein arginine deiminase Ⅱ (PADI2) was highly expressed in human and mouse retinoblastoma tissues due to the overexpression of E2 factor (E2F). By inhibiting PADI2 activity,...

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Identifiers

PMID: 37326108
DOI: 10.3892/or.2023.8583
PMCID: PMC10285604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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