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A Molecular-Level Account of the Antigenic Hantaviral Surface

30 Apr 2016

Abstract excerpt

Hantaviruses, a geographically diverse group of zoonotic pathogens, initiate cell infection through the concerted action of Gn and Gc viral surface glycoproteins. Here, we describe the high-resolution crystal structure of the antigenic ectodomain of Gn from Puumala hantavirus (PUUV), a causative agent of hemorrhagic fever with renal syndrome. Fitting of PUUV Gn into an electron cryomicroscopy reconstruction of...

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PMID: 27117403
DOI: 10.1016/j.celrep.2016.03.082

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