Article
Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care.
JAMA pediatrics - 1 May 2022
McDermott John H, Mahaveer Ajit, James Rachel A, Booth Nicola, Turner Mark, Harvey Karen E, Miele Gino, Beaman Glenda M, Stoddard Duncan C, Tricker Karen, Corry Rachel J, Garlick Julia, Ainsworth Shaun, Beevers Thomas, Bruce Iain A, Body Richard, Ulph Fiona, MacLeod Rhona, Roberts Peter L, Wilson Paul M, Newman William G
Abstract excerpt
Importance: Aminoglycosides are commonly prescribed antibiotics used for the treatment of neonatal sepsis. The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity (AIO). Current genotyping approaches take several days, which is unfeasible in acute settings. Objective: To develop a rapid point-of-care test (POCT) for the m.1555A>G variant before implementation of this technology in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.