Article
Predicting TERT promoter mutation status using 1H-MR spectroscopy and stretched-exponential model of diffusion-weighted imaging in IDH-wildtype diffuse astrocytic glioma without intense enhancement.
Neuroradiology - 1 Aug 2023
Yamashita Koji, Hatae Ryusuke, Kikuchi Kazufumi, Kuga Daisuke, Hata Nobuhiro, Yamamoto Hidetaka, Obara Makoto, Yoshimoto Koji, Ishigami Kousei, Togao Osamu
Abstract excerpt
PURPOSE: Isocitrate dehydrogenase (IDH)-wildtype diffuse astrocytic glioma with telomerase reverse transcriptase (TERT) promoter mutation is defined as glioblastoma by the WHO 2021 criteria, revealing that TERT promotor mutation is highly associated with tumor aggressiveness. The aim of this study was to identify features from MR spectroscopy (MRS) and multi-exponential models of DWI distinguishing wild-type TERT...
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