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Article

Multimodal MRI-based radiomic nomogram for predicting telomerase reverse transcriptase promoter mutation in IDH-wildtype histological lower-grade gliomas.

Medicine - 22 Dec 2023

Huo Xulei, Wang Yali, Ma Sihan, Zhu Sipeng, Wang Ke, Ji Qiang, Chen Feng, Wang Liang, Wu Zhen, Li Wenbin

Abstract excerpt

The presence of TERTp mutation in isocitrate dehydrogenase-wildtype (IDHwt) histologically lower-grade glioma (LGA) has been linked to a poor prognosis. In this study, we aimed to develop and validate a radiomic nomogram based on multimodal MRI for predicting TERTp mutations in IDHwt LGA. One hundred and nine IDH wildtype glioma patients (TERTp-mutant, 78; TERTp-wildtype, 31) with clinical, radiomic, and...

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Identifiers

PMID: 38134061
DOI: 10.1097/MD.0000000000036581
PMCID: PMC10735121

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